CDRI scientists working on two combinations of Covid-19 drugs

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Effort To Develop A Combination Effective On All Variants & Has No Side-Effects

There may be another drug available for Covid-19 treatment in the future.
After successful clinical trials of the antiviral drug, Umifenovir, for Covid treatment, scientists of the Central Drug Research Institute (CDRI) in the city are trying to develop another drug without any side-effects.

A team of scientists led by chief scientist Ravishankar is working on two combinations to provide the safest medication to coronavirus patients.

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“Experts say that a combination of antivirals with different mechanisms can be more effective to counter the viral pandemic. We are working on two combinations — Umifenovir with Molnupiravir (an antiviral) and Umifenovir with Niclosamide (anti-parasitic),” said Ravishankar

Molnupiravur drug has received only Emergency Use Authorisation in India and abroad. Though its usage showed reduced hospitalization during clinical trials, its biggest drawback are the side-effects, he added.

“Now, we are trying to keep a low dosage of Molnupiravir in its combination with Umifenovir which may weed out the side- effects such as the risk of cartilage and muscle damage. If successful, it will make Umifenovir more effective in Covid-19 treatment,” said the chief scientist.


The other combination is Umifenovir with Niclosamide. Niclosamide is known for its efficacy for Covid treatment but the biggest challenge is that its high dosage is required for treatment and that leads to side-effects. A safe and efficacious combination of Umifenovir with Niclosamide is being researched on and exact dosage in the combination that can give positive results, Ravishankar added.


CDRI director Prof Tapas Kundu said, “CDRI is working round-the-clock to develop drugs that can help in treating all variants of Covid-19 besides being economical and safe for people. We have achieved a major breakthrough with Umifenovir and are hopeful of developing a new drug to win the pandemic battle.”

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